Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

In systemic lupus erythematosus (SLE), perturbed immunoregulation underpins a pathogenic imbalance between regulatory and effector CD4+ T-cell activity.However, to date, the characterization of the CD4+ regulatory T cell (Treg) compartment in SLE has yielded conflicting results.Here we show that patients have an increased frequency of CD4+FOXP3+ ce

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SHORT ANALYSIS OF COMMERCIAL ADVERTISING

In DEX, commercial advertising is defined as the (commercial) activity which aimes by advertising (by prints, radio, television, movies, etc.), to point out public interest on certain goods, books, show, the use of services etc.A famous, advertised product remains in our memory.Many of us ask somehow annoyed: How some of the brands remain in our me

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Design Optimization of a Compact Double-Ended-Tuning-Fork-Based Resonant Accelerometer for Smart Spindle Applications

With the rapid developments of the Industrial Era 4.0, numerous sensors have been employed to facilitate and monitor the quality of machining processes.Among them, accelerometers play an important role in chatter detection and suppression for reducing the tool down-time and increasing manufacturing efficiency.To date, most commonly seen acceleromet

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